We developed an importation index that takes into account both travel volume and the extent of dengue incidence in the country of origin. It was the first sustained transmission of dengue in the european union since the 1920s. E gene analyses also suggested viral dissemination from venezuela into colombia 2012 and peru 1998, and from peru into ecuador 1999. The origins of dengue and chikungunya viruses in ecuador. University of groningen dengue in venezuela velasco, zoraida rug.
Dengue outbreak federated states of micronesia, 201220. There were over 75,000 cases of dengue in venezuela in 20, compared to 46,708 in 2012. Dengue fever is a virus transmitted to humans through bites from the aedes mosquito, a daybiting mosquito. A study on viral transmission, risk factors and clinical disease.
Dengue fever is a mosquitoborne tropical disease caused by the dengue virus. Mar, 2019 in 2012, the first dengue virus outbreak was reported on the portuguese island of madeira with 1080 confirmed cases. Madeira in 2012 arriving from 29 dengue endemic countries, almost 90% of them came from venezuela and brazil 6. According to official data from the ministry of health, cases of dengue rose by 40% in 20 compared to 2012. Molecular epidemiology suggests venezuela as the origin of. Each denv has four or more genetic groups or genotypes. Dhf shown as a proportion hatched bars of the total number of cases white.
The strange connection between cristiano ronaldo and a. During 2010 in medellin, the younger population presented a particularly high dengue incidence rate. Jul 19, 20 dengue outbreak federated states of micronesia, 201220. May 30, 2019 since 2012, venezuela has experienced a rapid deterioration of the public health situation due to an ongoing political and economic crisis. Equad proteins are the envelope proteins from denv with 4 amino acid changes t76r, q77e, w101r, and l107r. It is endemic in ample territories with many exposed. University of groningen dengue in venezuela velasco, zoraida. Des cas importes ont ete detectes dans trois autres pays europeens. The history of dengue outbreaks in the americas ncbi.
The 2012 portugals dengue outbreak was reported to be imported by a traveler from venezuela 41. Spatial analysis of dengue seroprevalence and modeling of. Diversity and composition of dengue virus type 2 in venezuela. This crisis has led to the collapse of the healthcare system, resulting in the reemergence of previously controlled or eliminated communicable diseases and to the lack of proper provision of sanitation, goods, services and food security 2,3. Risk is present throughout venezuela at elevations below 2,300 m 7,500 ft. Dengue outbreak recent cases of dengue have been confirmed in venezuela. Research articles the 2012 dengue outbreak in madeira. Dengue is among the most important mosquitoborne viral disease in the world. The number of cases of severe dengue in the same period was 238,454. Importantly, the past decade has also seen an upsurge in research on dengue virology, pathogenesis, and immunology and in development of antivirals, vaccines, and new vectorcontrol strategies that can positively impact dengue. Venezuela did not experience a single case of diphtheria between 2006 and 2015. During 2010 and 2011, a baseline crosssectional study was carried out as part of a dengue prospective cohort study. Comportamiento clinico epidemiologico del dengue en. Dengues breaking public health records in venezuela.
Symptoms typically begin three to fourteen days after infection. Dengue seroprevalence and risk factors for past and recent viral. For example, the highest incidence of cases in venezuela in 20 400 per 100 000 inhabitants were reported in children dengue incidence for dengue and dengue severe is higher in people between 10 and 19 years old 2, 8. Dengue virus serotype 4 denv4 reemerged in roraima state, brazil, 28 years after it was last detected in the country in 1982. There were 22,948 air travellers to madeira in 2012, originating from twentynine dengue endemic countries. A fundraising campaign was recently launched to help health professionals in venezuela provide basic care new projects. States and northeastern bahia state brazil during the 2010 and 2011 dengue virus seasons and for an. We investigated the seroprevalence among the population on madeira island four years after the outbreak. This disease used to be called breakbone fever because it sometimes causes severe joint and muscle pain that feels like bones are breaking. A randomized controlled trial of chloroquine for the.
Sep 14, 2014 today, dengue is regarded as the most prevalent and rapidly spreading mosquitoborne viral disease of human beings. Dengue y dengue grave en las americas, 19802012 se36. Epidemic dengue has become more common since the 1980s. Dengue fever is an increasing health problem in tropical and subtropical regions. Her team is collaborating with partners to study how the introduction of dengvaxia the only licensed vaccine currently available would impact on dengue hospitalized rates. Health experts have known about dengue fever for more than 200 years. Molecular epidemiology of dengue type 2 virus in venezuela. Health promotion activities in venezuela should aim at raising awareness at the. Although european dengue is a rare phenomenon, according to a phylogeographic analysis the dengue cases in madeira portugal in 2012 were caused for an strain which came through travelers from venezuela and produced an important outbreak due to the climate conditions.
Aug 18, 2016 infection with any one of the four dengue virus serotypes can cause disease that ranges from a mild febrile illness through to haemorrhagic fever and shock. Pdf knowledge, attitudes, and preventive practices regarding. In this regard, venezuela with more than 34 000 affected people poses a risk of introduction of chikungunya into madeira during the next months as occurred with dengue in 2012. Significant outbreaks of dengue fever tend to occur every five or. Research note virology molecular epidemiology suggests venezuela as the origin of the dengue outbreak in madeira, portugal in 201220 l. Dengue virus of serotype 1 denv1, probably imported from venezuela, caused this outbreak with autochthonous transmission by invasive aedes aegypti mosquitoes. Dengue virus igm serotyping by elisa with recombinant mutant. Between 2008 and 2015, there was one recorded case of measles, in 2012. An explosive epidemic occurred in madeira island portugal from october 2012 to february 20. Molecular epidemiology suggests venezuela as the origin of the. Epidemiology and disease burden of pediatric dengue in. From 26 september 2012 to 3 march 20, the autonomous province of madeira, portugal, reported its first dengue outbreak dengue 1 virus. Phylogeography of dengue virus serotype 4, brazil, 2010.
A longitudinal serological survey igg and spatial analysis were conducted to determine. Dengue is a mosquitoborne flavivirus found in tropical and subtropical regions of the world, mostly in urban and semiurban settings. From 2001 to 2012, more than 31 countries of the americas have notified a total of 9,847,209 cases of dengue paho 2012. Dengue fever is common in tropical areas, so take extra precautions if you travel somewhere with this type of climate. In colombia, peru and venezuela all four dengue serotypes were.
On september 26, 2012, a woman aged 35 years from kosrae in the federated states of micronesia fsm was hospitalized with fever, headache, muscle pain, vomiting, leukopenia, and thrombocytopenia. In conclusion, our phylogenetic analyses provide compelling evidence that venezuela is the source of denv1 introduced into madeira in 2012. Author summary dengue is a mosquitoborne viral disease of global impact. Epidemiology of dengue in latin america journal of the. Each year, an estimated 390 million people are infected.
Number of reported dengue cases in venezuela and aragua from 2001 to 2012. In venezuela, dengue is endemic with the cocirculation of the 4 viral serotypes. It is therefore important the gauge the impacts of infected immigrants of the dynamics of vector. Zika transmission in venezuela is associated with aedes mosquitoes as well as dengue and chikungunya causing 3 diseases coexisting in. Request pdf dengue en america latina y venezuela dengue is the commonest viral disease transmitted by arthropods at worldwide level. The disease is caused by four serologically and genetically distinct viruses termed dengue virus denv 1, 2, 3 and 4. By the late 1990s, dengue was the most important mosquitoborne disease affecting humans after malaria, with around 40 million cases of dengue fever and several hundred thousand cases of dengue hemorrhagic fever each year. Maracay is the fourth largest city of venezuela and has become highly endemic for dengue transmission and dhf epidemics. A risk to anyone traveling to a tropical or subtropical region of the world where dengue virus is found. The total number of dengue deaths from 2001 to 2012 was 4,341, with a case fatality rate cfr of 1.
In the last 50 years, dengue incidence has increased 30fold, worldwide. Dengue fever is an infectious disease carried by mosquitoes and caused by any of four related dengue viruses. Risk is present yearround, with peak transmission from june to december. Dengue seroprevalence and risk factors for past and recent.
Dengue virus igm serotyping by elisa with recombinant. Since 2012, venezuela has experienced a rapid deterioration of the public health situation due to an ongoing political and economic crisis. Integrated management strategy for dengue prevention and. To determine the dengue infection associatedrisk factors in san mateo, anzoategui, venezuela. It is the fastest spreading vectorborne viral disease and is now endemic in over 100 countries, resulting in 40% of the worlds population living in an area at risk for dengue. Castrorodriguez and col leagues 23 established direct and indi rect costs for three periods, including an epidemic period in 2012. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin rash. Risk factors associated with dengue transmission and.